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Robert L. Bronaugh; Howard I. Maibach

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Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition presents new chapters on mathematical models, cutaneous metabolism, prediction of percutaneous absorption, in vitro absorption methodology, dermal decontamination, concentration of chemicals in skin, transdermal drug delivery, mechanisms of absorption, safety evaluation of cosmetics, absorption of drugs and cosmetic ingredients, and nail penetration.

Contenido

- Preface to the Third Edition
- Preface to the First Edition
- Contributors

I. Mechanisms of Absorption

1. Mathematical Models in Percutaneous Absorption
2. Cutaneous Metabolism During In Vitro Percutaneous Absorption
3. Cutaneous Metabolism of Xenobiotics
4. Occlusion Does Not Uniformly Enhance Penetration In Vivo
5. Regional Variation in Percutaneous Absorption
6. In Vivo Relationship Between Percutaneous Absorption and Transepidermal Water Loss
7. Skin Contamination and Absorption of Chemicals from Water and Soil
8. Characterization of Molecular Transport Across Human Stratum Corneum In Vivo
9. Relationship Between H-Bonding of Penetrants to Stratum Corneum Lipids and Diffusion
10. In Vivo Percutaneous Absorption: A Key Role for Stratum Corneum/Vehicle Partitioning

II. Methodology

11. In Vivo Methods for Percutaneous Absorption Measurements
12. Determination of Percutaneous Absorption by In Vitro Techniques
13. Will Cutaneous Levels of Absorbed Material Be Systemically Absorbed?
14. Dermal Decontamination and Percutaneous Absorption
15. Partitioning of Chemicals from Water into Powdered Human Stratum Corneum (Callus) - A Model Study
16. In Vitro Percutaneous Absorption of Model Compounds Glyphosate and Malathion from Cotton Fabric into and Through Human Skin
17. Vaginal Absorption of Prostaglandin E1 in Rhesus Monkey
18. Human Cadaver Skin Viability for In Vitro Percutaneous Absorption: Storage and Detrimental Effects of Heat Separation and Freezing
19. Interrelationships in the Dose Response of Percutaneous Absorption
20. Blood Flow as a Technology in Percutaneous Absorption: The Assessment of the Cutaneous Microcirculation by Laser Doppler and Photoplethysmographic Techniques
21. Drug Concentration in the Skin
22. Stripping Method for Measuring Percutaneous Absorption In Vivo
23. Tape-Stripping Technique
24. Interference with Stratum Corneum Lipid Biogenesis: An Approach to Enhance Transdermal Drug Delivery
25. Percutaneous Drug Delivery to the Hair Follicle
26. Relative Contributions of Human Skin Layers to Partitioning of Chemicals with Varying Lipophilicity
27. Effect of Single Versus Multiple Dosing in Percutaneous Absorption
28. Measurement of Short-Term Dermal Uptake In Vitro Using Accelerator Mass Spectrometry
29. New Developments in the Methodology Available for the Assessment of Topical Corticosteroid-Induced Skin Blanching
30. Raman Spectroscopy
31. Stratum Corneum and Barrier Performance: A Model Lamellar Structural Approach
32. Role of In Vitro Release Measurement in Semisolid Dosage Forms
33. Percutaneous Absorption of Salicylic Acid, Theophylline, 2,4-Dimethylamine, Diethyl Hexyl Phthalic Acid, and p-Aminobenzoic Acid in the Isolated Perfused Porcine Skin Flap Compared to Humans In Vivo
34. Transepidermal Water Loss Measurements for Assessing Skin Barrier Functions During In Vitro Percutaneous Absorption Studies

III. Drug and Cosmetic Absorption

35. Percutaneous Penetration as a Method of Delivery to Skin and Underlying Tissues
36. Phonophoresis
37. Facilitated Transdermal Delivery by Iontophoresis
38. Percutaneous Penetration as It Relates to the Safety Evaluation of Cosmetic Ingredients
39. Percutaneous Absorption of Fragrances
40. Hair Dye Absorption
41. Percutaneous Absorption of Alpha-Hydroxy Acids in Human Skin
42. Optimizing Patch Test Delivery: A Model
43. Permeation of N-Nitrosamines Through Human Skin
44. Nail Penetration: Focus on Topical Delivery of Antifungal Drugs for Onychomycosis Treatment
45. Topical Dermatological Vehicles: A Holistic Approach
46. Human In Vivo and In Vitro Hydroquinone Topical Bioavailability, Metabolism, and Disposition
47. Human Skin In Vitro Percutaneous Absorption of Gaseous Ethylene Oxide from Fabric
48. In Vivo Percutaneous Absorption of Acetochlor in Rhesus Monkey: Dose Response and Exposure Risk Assessment
49. The Development of Skin Barrier Function in the Neonate
50. Percutaneous Absorption of Sunscreens
51. Microemulsions
52. Bioavailability of [[superscript 14]C]Hydroquinone in F344 Rat and Rhesus Monkey
53. Dermatopharmacokinetics of Topical BCX-34 Cream in Human Skin
54. In Vitro Cutaneous Disposition of a Topical Diclofenac Lotion in Human Skin: Effect of a Multidose Regimen
55. An Innovative Method to Determine Percutaneous Absorption: Real-Time Breath Analysis and Physiologically Based Pharmacokinetic Modeling
56. Role of Calcium Ions in Relation to Skin Barrier Function

Index

Contacto

Editorial: Marcel Dekker