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Jens Thiele; Peter Elsner

Datos Técnicos

Notas del Editor

Are free radicals and reactive oxygen species relevant to dermatopathology? Do antioxidants protect against free-radical-mediated cutaneous diseases and aging? To these and further current questions in the rapidly progressing field of basic and applied skin research, this up-to-date volume provides a scientific basis. It presents state-of-the-art reviews on the progress in detection of free radicals and antioxidants and their responses to environmental oxidative stressors. Furthermore, several expert contributions focus on the exciting developments in oxidative DNA damage and UVB- and UVA-induced signal transduction in skin. Finally, information is given on new antioxidant protection strategies against skin carcinogenesis and skin aging which may be fundamental for the pharmaceutical or skin-care products of tomorrow.

Due to its unique and up-to-date collection of state-of-the-art contributions by many of the world’s leading scientists in the field, this book will be essential reading for dermatologists, cosmetologists, pharmacologists and environmental

Contenido

- Preface

- Detection of Free Radicals in Skin

- Detection of Free Radicals in Skin: A Review of the Literature and New Developments
- Electron Paramagnetic Resonance Detection of Free Radicals in UV-Irradiated Human and Mouse Skin

- Detection of Antioxidants in Skin and Antioxidant Response to Environmental Stress

- The Antioxidant Network of the Stratum Corneum
- Activity of Alpha-Lipoic Acid in Protection against Oxidative Stress in Skin
- Ozone: An Emerging Oxidative Stressor to Skin

Oxidative DNA Damage

- Effects of UV and Visible Radiations on Cellular DNA
- Sequence-Specific DNA Damage Induced by UVA Radiation in the Presence of Endogenous and Exogenous Photosensitizers

UVA and UVB Induced Signal Transduction in Skin

- UV-Induced Oxidative Stress and Photoaging
- UVA and Singlet Oxygen as Inducers of Cutaneous Signaling Events
- Reactive Oxygen Species as Mediators of UVB-Induced Mitogen-Activated Protein Kinase Activation in Keratinocytes

Antioxidant Protection against Oxidative Stress in Skin

- Antioxidants in Chemoprevention of Skin Cancer
- Radical Reactions of Carotenoids and Potential Influence on UV Carcinogenesis
- Protective Effects of Topical Antioxidants in Humans
- The Antioxidative Potential of Melatonin in the Skin
- Bioconversion of Vitamin E Acetate in Human Skin

- Author Index
- Subject Index

Contacto

Editorial: Karger, S Publishers